The 2nd International Conference on Energy and AI (ICEAI, 2021) aims to provide an authoritative platform for leading academic scientists and research scholars to exchange and share the latest research progress in the cross-disciplinary area of energy and AI, focusing on the innovative applications of AI to address the critical challenges in energy systems, energy materials, energy chemistry, energy utilization & conversion, energy & society, as well as other important pressing issues. The conference also aims to promote the development of AI technologies for advancing the energy, decarbonization and sustainable development, such as data-driven approaches, optimization algorithms and AI ethics. ICEAI is a flagship conference for cutting-edge researches at the interface between the energy and AI. It will foster new collaborations between academia and industry in the fields of energy and AI.